Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking

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Paper (help)
Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking
Authors: Jonathan Benjamin, Lin Li, Chavis Patterson, Benjamin D. Greenberg, Dennis L. Murphy, Dean H. Hamer
Citation: Nature genetics 12 (1): 81-84. 1996 January
Database(s): PubMed (PMID/8528258)
DOI: 10.1038/ng0196-81.
Link(s): http://www.cbd.ucla.edu/downloads/nature_genetics.pdf
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Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking reports a personality genetics on the exon 3 VNTR genetic polymorphism in the DRD4 gene with personality traits assessed with NEO PI-R.

The study is described in the popular science book Living with our genes: why they matter more than you think.

[edit] Subjects

Subject group (help)
Heterosexual and homosexual Americans
Subjects/♂/♀: 315 /  /
Age: 32.4 ±10.8 (18–71)
Nationality: American
Approval: define approval
Databases:

A group of 315 heterosexual and homosexual Americans were included in the study. The American group had a mean age of 32.4 with a range from 18 to 71.

Most subjects were males and white.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
DRD4 Exon 3 VNTR short/short NEO PI-R Neuroticism 53.1 9.1 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Neuroticism 52.3 9.2 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Extraversion 53.4 9.7 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Extraversion 57.3 10.3 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Openness to experience 58.5 9.7 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Openness to experience 59.7 11.1 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Agreeableness 46.1 9.5 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Agreeableness 48.3 9.9 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Conscientiousness 45.9 10.3 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Conscientiousness 43.2 10.7 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Warmth 49.3 10.1 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Warmth 52.6 8.9 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Gregariousness 54.4 10.2 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Gregariousness 55.9 9.4 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Assertiveness 51.5 9.3 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Assertiveness 51.6 10.8 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Activity 54.0 9.0 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Activity 53.3 11.0 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Excitement seeking 54.2 8.6 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Excitement seeking 57.4 8.6 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Positive emotions 52.6 9.7 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Positive emotions 56.5 9.7 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Competence 50.8 9.5 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Competence 50.5 10.7 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Order 46.3 9.5 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Order 44.9 10.1 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Dutifulness 46.8 9.9 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Dutifulness 44.8 9.6 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Achievement striving 48.8 9.6 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Achievement striving 47.4 10.1 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Self-discipline 41.7 9.5 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Self-discipline 42.6 11.0 98 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR short/short NEO PI-R Deliberation 47.6 9.9 217 Heterosexual and homosexual Americans 8528258
DRD4 Exon 3 VNTR long NEO PI-R Deliberation 44.4 9.2 98 Heterosexual and homosexual Americans 8528258

[edit] Related papers

  1. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking
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