Potential role of the estrogen receptor gene (ESR1) in anxiety

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Potential role of the estrogen receptor gene (ESR1) in anxiety
Authors: David E. Comings, D. Muhleman, P. Johnson, J. P. MacMurray
Citation: Molecular Psychiatry 4 (4): 374-377. 1999 July
Database(s): PubMed (PMID/10483055)
DOI: Define doi.
Link(s): http://www.nature.com/mp/journal/v4/n4/pdf/4000503a.pdf
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Potential role of the estrogen receptor gene (ESR1) in anxiety reports a personality genetics study on the TA repeat genetic polymorphism in the ESR1 gene and personality traits assessed with SCL-90-R.

[edit] Subjects

Subject group #1 (help)
American male substance abusers
Subjects/♂/♀: 179 / 179 / 0
Age: 40.9 ±6.91 (–)
Nationality: American
Approval: IRB
Databases:

Group 1 of 179 american male substance abusers with 179 males and 0 females were included in the study. The American group had a mean age of 40.9. The study on the human subjects was approved by the IRB. The substance abuse was alcohol dependence, amphetamine, cannabis, cacaine, opioid.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
ESR1 TA repeat long/long SCL-90-R Anxiety 1.69 0.93 40 American male substance abusers 10483055
ESR1 TA repeat long/short SCL-90-R Anxiety 1.39 0.87 89 American male substance abusers 10483055
ESR1 TA repeat short/short SCL-90-R Anxiety 1.03 0.76 50 American male substance abusers 10483055
ESR1 TA repeat long/long SCL-90-R Depression 1.92 0.82 40 American male substance abusers 10483055
ESR1 TA repeat long/short SCL-90-R Depression 1.92 0.84 89 American male substance abusers 10483055
ESR1 TA repeat short/short SCL-90-R Depression 1.83 0.81 50 American male substance abusers 10483055
ESR1 TA repeat long/long SCL-90-R Hostility 1.51 1.01 40 American male substance abusers 10483055
ESR1 TA repeat long/short SCL-90-R Hostility 1.33 0.90 89 American male substance abusers 10483055
ESR1 TA repeat short/short SCL-90-R Hostility 1.23 0.93 50 American male substance abusers 10483055
ESR1 TA repeat long/long SCL-90-R Interpersonal sensitivity 1.78 0.92 40 American male substance abusers 10483055
ESR1 TA repeat long/short SCL-90-R Interpersonal sensitivity 1.58 0.74 89 American male substance abusers 10483055
ESR1 TA repeat short/short SCL-90-R Interpersonal sensitivity 1.44 0.93 50 American male substance abusers 10483055
ESR1 TA repeat long/long SCL-90-R Obsessive-compulsive 1.65 0.97 40 American male substance abusers 10483055
ESR1 TA repeat long/short SCL-90-R Obsessive-compulsive 1.53 0.88 89 American male substance abusers 10483055
ESR1 TA repeat short/short SCL-90-R Obsessive-compulsive 1.39 0.83 50 American male substance abusers 10483055
ESR1 TA repeat long/long SCL-90-R Paranoid ideation 1.66 1.0 40 American male substance abusers 10483055
ESR1 TA repeat long/short SCL-90-R Paranoid ideation 1.57 0.84 89 American male substance abusers 10483055
ESR1 TA repeat short/short SCL-90-R Paranoid ideation 1.35 0.81 50 American male substance abusers 10483055
ESR1 TA repeat long/long SCL-90-R Phobic anxiety 1.00 0.94 40 American male substance abusers 10483055
ESR1 TA repeat long/short SCL-90-R Phobic anxiety 0.65 0.69 89 American male substance abusers 10483055
ESR1 TA repeat short/short SCL-90-R Phobic anxiety 0.55 0.71 50 American male substance abusers 10483055
ESR1 TA repeat long/long SCL-90-R Psychoticism 1.35 0.92 40 American male substance abusers 10483055
ESR1 TA repeat long/short SCL-90-R Psychoticism 1.13 0.71 89 American male substance abusers 10483055
ESR1 TA repeat short/short SCL-90-R Psychoticism 0.95 0.76 50 American male substance abusers 10483055
ESR1 TA repeat long/long SCL-90-R Somatization 1.29 0.97 40 American male substance abusers 10483055
ESR1 TA repeat long/short SCL-90-R Somatization 1.17 0.89 89 American male substance abusers 10483055
ESR1 TA repeat short/short SCL-90-R Somatization 0.89 0.64 50 American male substance abusers 10483055
ESR1 TA repeat long/long SCL-90-R SCL-90-R 60.17 20.4 40 American male substance abusers 10483055
ESR1 TA repeat long/short SCL-90-R SCL-90-R 57.69 18.9 89 American male substance abusers 10483055
ESR1 TA repeat short/short SCL-90-R SCL-90-R 47.97 17.0 50 American male substance abusers 10483055

[edit] Critique

  1. The personality inventory is called "SCL-90", but the referenced article is SCL-90-R
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