Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment

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Paper (help)
Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment
Authors: Raymond J. Dolan, Christopher J. Bench, R. G. Brown, Lynette C. Scott, Karl J. Friston, Richard S. J. Frackowiak
Citation: Journal of Neurology, Neurosurgery, and Psychiatry 55 : 768-773. 1992 September
Database(s): PubMed (PMID/1402966)
DOI: Define doi.
Link(s): http://jnnp.bmj.com/cgi/reprint/55/9/768
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1015099
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Extract: Talairach coordinates from linked PDF: CSV-formated wiki-formated

Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment reports a positron emission tomography study in a group of patients with major depressive disorder.

There were two tracers inhaled: oxygene-15 O2 and oxygene-15 CO2.

Contents

[edit] Subjects

Subject information is available in Table 1.
Subject group (help)
Major depressive disorder patients with cognitive impairment
Subjects/♂/♀: 10 / 4 / 6
Age: 60.9 ±7.8 (–)
Nationality: British
Approval: define approval
Databases:

A group of 10 major depressive disorder patients with cognitive impairment with 4 males and 6 females were included in the study.

The British group had a mean age of 60.9.
Subject group (help)
Major depressive disorder patients without cognitive impairment
Subjects/♂/♀: 10 / 8 / 2
Age: 53.2 ±14.8 (–)
Nationality: British
Approval: define approval
Databases:

A group of 10 major depressive disorder patients without cognitive impairment with 8 males and 2 females were included in the study. The British group had a mean age of 53.2.

33 subjects recruited from district psychiatric services in north London, UK and National Hospital for Neurology and Neurosurgery. were included in the study. The subjects were split in two groups depending of their score on the MMSE: Those subjects score 29 or more as "without" cognitive impairment and those subjects scoring 25 or below as "with" cognitive impairment. Subjects in the intermediate range were not compared.

There seems also to have been a fourth group of subjects of 23 normal subjects (see text on page 770 and Figure 3 caption. An analysis was made and results mention in the text and displayed in a figure, but no quantitative results (Talairach coordinates) are given.

[edit] Results

Table 2 has 7 coordinates but is from two different contrasts (see text 769, column 2). The p-value was set to <0.05 Bonferroni corrected per plane, i.e., not the whole brain/full volume.

[edit] Depressed without cogitive impairment versus with cognitive impairment

This contrast shows the area where cognitive impaired patients have a decrease in cerebral blood flow compared to patients without cognitive impairment.
Experiment #1 : Depressed without cogitive impairment versus with cognitive impairment (help)
Description: missing description
Scanning:
Topic: Major depressive disorder
Analysis:
Databases:
1 Left medial frontal cortex -8 48 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 Left medial frontal cortex -6 52 4 Brede Database Brede Wiki NeuroSynth SumsDB Not available
3 Left medial frontal cortex -6 54 8 Brede Database Brede Wiki NeuroSynth SumsDB Not available
4 Left medial frontal cortex -6 54 12 Brede Database Brede Wiki NeuroSynth SumsDB Not available

[edit] Depressed with cognitive impaired versus without cognitive impairment


Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
5 Cerebellar vermis 8 -66 -12 Brede Database Brede Wiki NeuroSynth SumsDB Not available
6 Cerebellar vermis 10 -60 -8 Brede Database Brede Wiki NeuroSynth SumsDB Not available
7 Cerebellar vermis 8 -48 -4 Brede Database Brede Wiki NeuroSynth SumsDB Not available
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