Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI

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Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
Authors: Ichiro Kusumi, Takuya Masui, Chihiro Kakiuchi, Katsuji Suzuki, Tatsuyuki Akimoto, Ryota Hashimoto, Hiroshi Kunugi, Tadafumi Kato, Tsukasa Koyama
Citation: Neuroscience Letters 391 (1-2): 7-10. 2005 December
Database(s): PubMed (PMID/16154272)
DOI: 10.1016/j.neulet.2005.08.023.
Link(s): http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/8420/1/nsl05.pdf
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Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI reports a personality genetics study with the XBP1 gene and TCI and NEO-FFI inventories.

One single polymorphism was examined, the C-116G against the Japanese versions of TCI and NEO-FFI.

The same polymorphism was examined in the personality genetics study XBP1 gene polymorphism (-116C/G) and personality.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
XBP1 C-116G C/C TCI Novelty seeking 48.9 3.4 7 Japanese males 16154272
XBP1 C-116G C/G TCI Novelty seeking 49.9 6.0 71 Japanese males 16154272
XBP1 C-116G G/G TCI Novelty seeking 50.1 6.0 63 Japanese males 16154272
XBP1 C-116G C/C TCI Harm avoidance 51.6 4.5 7 Japanese males 16154272
XBP1 C-116G C/G TCI Harm avoidance 52.5 8.0 71 Japanese males 16154272
XBP1 C-116G G/G TCI Harm avoidance 51.8 8.3 63 Japanese males 16154272
XBP1 C-116G C/C TCI Reward dependence 42.4 4.9 7 Japanese males 16154272
XBP1 C-116G C/G TCI Reward dependence 42.6 5.4 71 Japanese males 16154272
XBP1 C-116G G/G TCI Reward dependence 42.1 4.8 63 Japanese males 16154272
XBP1 C-116G C/C TCI Persistence 13.4 1.7 7 Japanese males 16154272
XBP1 C-116G C/G TCI Persistence 13.5 2.8 71 Japanese males 16154272
XBP1 C-116G G/G TCI Persistence 12.6 2.8 63 Japanese males 16154272
XBP1 C-116G C/C TCI Self-directedness 67.4 6.9 7 Japanese males 16154272
XBP1 C-116G C/G TCI Self-directedness 69.8 10.5 71 Japanese males 16154272
XBP1 C-116G G/G TCI Self-directedness 69.0 10.1 63 Japanese males 16154272
XBP1 C-116G C/C TCI Cooperativeness 71.9 7.0 7 Japanese males 16154272
XBP1 C-116G C/G TCI Cooperativeness 71.1 7.3 71 Japanese males 16154272
XBP1 C-116G G/G TCI Cooperativeness 70.6 6.5 63 Japanese males 16154272
XBP1 C-116G C/C TCI Self-transcendence 25.7 4.3 7 Japanese males 16154272
XBP1 C-116G C/G TCI Self-transcendence 27.9 6.6 71 Japanese males 16154272
XBP1 C-116G G/G TCI Self-transcendence 26.8 5.7 63 Japanese males 16154272
XBP1 C-116G C/C TCI Novelty seeking 51.4 5.3 17 Japanese females 16154272
XBP1 C-116G C/G TCI Novelty seeking 50.3 6.1 45 Japanese females 16154272
XBP1 C-116G G/G TCI Novelty seeking 50.3 8.2 45 Japanese females 16154272
XBP1 C-116G C/C TCI Harm avoidance 55.2 9.6 17 Japanese females 16154272
XBP1 C-116G C/G TCI Harm avoidance 52.2 7.4 45 Japanese females 16154272
XBP1 C-116G G/G TCI Harm avoidance 55.7 9.6 45 Japanese females 16154272
XBP1 C-116G C/C TCI Reward dependence 43.9 3.6 17 Japanese females 16154272
XBP1 C-116G C/G TCI Reward dependence 44.2 4.6 45 Japanese females 16154272
XBP1 C-116G G/G TCI Reward dependence 44.0 4.8 45 Japanese females 16154272
XBP1 C-116G C/C TCI Persistence 12.1 2.2 17 Japanese females 16154272
XBP1 C-116G C/G TCI Persistence 12.8 3.1 45 Japanese females 16154272
XBP1 C-116G G/G TCI Persistence 13.2 2.5 45 Japanese females 16154272
XBP1 C-116G C/C TCI Self-directedness 68.8 10.3 17 Japanese females 16154272
XBP1 C-116G C/G TCI Self-directedness 73.7 7.2 45 Japanese females 16154272
XBP1 C-116G G/G TCI Self-directedness 69.6 10.4 45 Japanese females 16154272
XBP1 C-116G C/C TCI Cooperativeness 73.2 5.4 17 Japanese females 16154272
XBP1 C-116G C/G TCI Cooperativeness 72.8 5.5 45 Japanese females 16154272
XBP1 C-116G G/G TCI Cooperativeness 72.3 7.0 45 Japanese females 16154272
XBP1 C-116G C/C TCI Self-transcendence 27.2 5.2 17 Japanese females 16154272
XBP1 C-116G C/G TCI Self-transcendence 28.2 6.3 45 Japanese females 16154272
XBP1 C-116G G/G TCI Self-transcendence 27.0 5.6 45 Japanese females 16154272
XBP1 C-116G C/C NEO-FFI Neuroticism 23.7 8.6 7 Japanese males 16154272
XBP1 C-116G C/G NEO-FFI Neuroticism 25.1 6.9 61 Japanese males 16154272
XBP1 C-116G G/G NEO-FFI Neuroticism 24.9 7.8 51 Japanese males 16154272
XBP1 C-116G C/C NEO-FFI Extraversion 24.3 5.5 7 Japanese males 16154272
XBP1 C-116G C/G NEO-FFI Extraversion 24.2 10.6 61 Japanese males 16154272
XBP1 C-116G G/G NEO-FFI Extraversion 21.8 5.7 51 Japanese males 16154272
XBP1 C-116G C/C NEO-FFI Openness to experience 28.9 7.3 7 Japanese males 16154272
XBP1 C-116G C/G NEO-FFI Openness to experience 29.2 5.7 61 Japanese males 16154272
XBP1 C-116G G/G NEO-FFI Openness to experience 28.6 5.5 51 Japanese males 16154272
XBP1 C-116G C/C NEO-FFI Agreeableness 31.6 4.7 7 Japanese males 16154272
XBP1 C-116G C/G NEO-FFI Agreeableness 28.2 5.9 61 Japanese males 16154272
XBP1 C-116G G/G NEO-FFI Agreeableness 27.8 5.2 51 Japanese males 16154272
XBP1 C-116G C/C NEO-FFI Conscientiousness 29.7 8.4 7 Japanese males 16154272
XBP1 C-116G C/G NEO-FFI Conscientiousness 26.7 6.8 61 Japanese males 16154272
XBP1 C-116G G/G NEO-FFI Conscientiousness 24.2 5.7 51 Japanese males 16154272
XBP1 C-116G C/C NEO-FFI Neuroticism 32.5 6.2 13 Japanese females 16154272
XBP1 C-116G C/G NEO-FFI Neuroticism 25.0 6.3 37 Japanese females 16154272
XBP1 C-116G G/G NEO-FFI Neuroticism 28.1 7.4 37 Japanese females 16154272
XBP1 C-116G C/C NEO-FFI Extraversion 22.6 5.7 13 Japanese females 16154272
XBP1 C-116G C/G NEO-FFI Extraversion 24.2 6.1 37 Japanese females 16154272
XBP1 C-116G G/G NEO-FFI Extraversion 22.3 7.2 37 Japanese females 16154272
XBP1 C-116G C/C NEO-FFI Openness to experience 30.0 6.3 13 Japanese females 16154272
XBP1 C-116G C/G NEO-FFI Openness to experience 29.3 4.9 37 Japanese females 16154272
XBP1 C-116G G/G NEO-FFI Openness to experience 29.7 4.2 37 Japanese females 16154272
XBP1 C-116G C/C NEO-FFI Agreeableness 29.1 5.7 13 Japanese females 16154272
XBP1 C-116G C/G NEO-FFI Agreeableness 28.9 5.1 37 Japanese females 16154272
XBP1 C-116G G/G NEO-FFI Agreeableness 29.6 4.7 37 Japanese females 16154272
XBP1 C-116G C/C NEO-FFI Conscientiousness 22.0 7.5 13 Japanese females 16154272
XBP1 C-116G C/G NEO-FFI Conscientiousness 25.6 7.3 37 Japanese females 16154272
XBP1 C-116G G/G NEO-FFI Conscientiousness 24.8 6 37 Japanese females 16154272

[edit] Critique

  1. The claimed association between XBP1.C-116G and neuroticism among females probably gets a high statistical value from the heterozygotes; the homozygotes are more equal.
  2. 36 test are performed. A P-value on 0.003 as it is for the claimed association between neuroticism and C-116G for females are not that significant in the light of so many tests performed.
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