STin2

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STin2
Variations:

5-HTTVNTR
VNTR-17

Category: STin2
Parents:

Serotonin transporter gene
Variable number of tandem repeats

Children:
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Ontologies: MeSH NeuroLex Wikidata Wikipedia
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STin2 is a genetic variant in the serotonin transporter gene (SLC6A4). It is a variable number of tandem repeats (VNTR) polymorphism in intron 2. It has also been called VNTR-17[1]

The alleles of STin2 are typically "9", "10", and "12". 9 repeats are rare and in statistical analysis it is sometimes aggregated into the 10 repeat group.

In some reports the "10" allele (as compared to the "12") has been labeled as the "bad" allele, e.g., in terms of suicide,[2] depression treatment response.[3]

STin2 is mentioned in a SzGene meta-analysis among polymorphisms showing significant summary odds ratio with association with schizophrenia, though the effect size is small and the the heterogeneity is large.[4]

Contents

[edit] Linkage

  1. 5-HTTLPR

[edit] Papers

[edit] Depression treatment response

[edit] Meta-analysis

  1. Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review

[edit] Depression

  1. STin2 variant and family history of suicide as significant predictors of suicide completion in major depression

[edit] Schizophrenia

  1. Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia

[edit] Irritable bowel syndrome

  1. 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene and irritable bowel syndrome: effect of bowel habit and sex


[edit] Personality genetics

  1. Vormfelde (missing year). "Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms". missing journal missing volume: missing pages.
  2. Low level of harm avoidance is associated with serotonin transporter functional haplotype in alcohol-dependent individuals
  3. Deary (1999). "Neuroticism and polymorphisms in the serotonin transporter gene". Psychiatric Genetics missing volume: missing pages.
  4. Polymorphisms of the serotonin transporter gene (5-HTTLPR, A/G SNP in 5-HTTLPR, and STin2 VNTR) and their relation to personality traits in healthy individuals from Russia
  5. Gelernter (1998). "Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects". missing journal missing volume: missing pages.
  6. Vera E. Golimbet (2003). "Serotonin transporter gene polymorphism and personality traits measured by MMPI". missing journal missing volume: missing pages.
  7. Melke (2001). "Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women". missing journal missing volume: missing pages.
  8. Shih-Jen Tsai (2002). "Serotonin transporter genetic polymorphisms and harm avoidance in the Chinese". Psychiatric Genetics missing volume: missing pages.

[edit] References

  1. Serotonin transporter gene polymorphism and personality traits measured by MMPI
  2. Catalina Lopez de Lara, Alexandre Dumais, Guy Rouleau, Alain Lesage, Mimi Dumont, Nadia Chawky, Martin Alda, Chawki Benkelfat, Gustavo Turecki (2006). "STin2 variant and family history of suicide as significant predictors of suicide completion in major depression". Biological Psychiatry 59(2): 114-120.
  3. D. K. Kim (2000). "Serotonin transporter gene polymorphism and antidepressant treatment". NeuroReport missing volume: missing pages.
  4. Nicole C. Allen (2008). "Systematic meta-analysis and field synopsis of genetic association studies in schizophrenia: the SzGene database". Nature Genetics missing volume: missing pages.
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