Seasonal changes in brain serotonin transporter binding in short serotonin transporter linked polymorphic region-allele carriers but not in long-allele homozygotes

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Paper (help)
Seasonal changes in brain serotonin transporter binding in short serotonin transporter linked polymorphic region-allele carriers but not in long-allele homozygotes
Authors: Jan Kalbitzer, David Erritzøe, Klaus Kähler Holst, Finn Årup Nielsen, Lisbeth Marner, Szabolcs Lehel, Tine Arentzen, Terry L. Jernigan, Gitte Moos Knudsen
Citation: Biological Psychiatry 67 (11): 1033-1039. 2010 June
Database(s): Google Scholar cites PubMed (PMID/20110086)
DOI: 10.1016/j.biopsych.2009.11.027.
Link(s): http://precedings.nature.com/documents/2259/version/1
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Seasonal changes in brain serotonin transporter binding in short serotonin transporter linked polymorphic region-allele carriers but not in long-allele homozygotes (a previous draft was called Seasonal changes in brain serotonin transporter binding in short 5-HTTLPR-allele carriers but not in long-allele homozygotes) reports positron emission tomography study using the DASB ligand examining the serotonin transporter binding potential its correlation to seasonality, here the time of year the subjects were scanned.

The study was described in Danish media.[1][2][3][4]

Contents

[edit] Subjects

Subject group #1 (help)
Healthy
Subjects/♂/♀: 57 / 37 / 20
Age: 34 ±19 (–)
Nationality: Danish
Approval: Ethics Committee of Copenhagen and Frederiksberg
Databases:

Group 1 of 57 healthy with 37 males and 20 females were included in the study. The Danish group had a mean age of 34. The study on the human subjects was approved by the Ethics Committee of Copenhagen and Frederiksberg.

[edit] Results

[edit] Volume-of-interest analysis

Daylight length and DASB binding regression coefficient:

  • Putamen: -0.0438 BPnd/(100 minutes), p=0.001
  • Caudate: -0.063 BPnd/(100 minutes), p=0.037
  • Thalamus: -0.0299 BPnd/(100 minutes), p=0.099
  • Midbrain: 0.0192 BPnd/(100 minutes), p=0.715

[edit] Voxel-based analysis

[edit] DASB binding and daylight correlation


Anatomy
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1 Left putamen -30 0 4 8 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 Border of right putamen 22 -4 16 34 Brede Database Brede Wiki NeuroSynth SumsDB Not available

[edit] Interactions


Anatomy
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Entry not completed (help)

[edit] Critique

  • Typo: "high-binding regions determined where BPnd < 1" should have been "high-binding regions determined where BPnd > 1"

[edit] Related papers

  1. Brain serotonin transporter binding of (123I)ADAM: within-subject variation between summer and winter data
  2. Light-dependent alteration of serotonin-1A receptor binding in cortical and subcortical limbic regions in the human brain
  3. No seasonal variation in human midbrain serotonin transporter availability in Taiwan
  4. Seasonal and circadian monoamine variations in human brains examined post mortem
  5. Seasonal variation in human brain serotonin transporter binding
  6. Seasonal variation of availability of serotonin transporter binding sites in healthy female subjects as measured by (123I)-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography
  7. Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to (11C) DASB binding in the living human brain

[edit] References

  1. Cecilie Cronwald, "Vinterdepression styret af gen", videnskab dk, 16. februar 2010.
  2. Gen afgørende for vinterdepression, DepressionsForeningen, 17. februar 2010.
  3. "Vinterdepression er styret af gen", 16. februar 2010.
  4. Ny viden om vinterdepression, DR Update, 17. februar 2010.
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