Seasonal variation of availability of serotonin transporter binding sites in healthy female subjects as measured by (123I)-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography

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Seasonal variation of availability of serotonin transporter binding sites in healthy female subjects as measured by (123I)-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography
Authors: Alexander Neumeister, Walter Pirker, Matthäus Willeit, Nicole Praschak-Rieder, Susanne Asenbaum, Thomas Brücke, Siegfried Kasper
Citation: Biological Psychiatry 47 (2): 158-160. 2000 January
Database(s): PubMed (PMID/10664833)
DOI: 10.1016/S0006-3223(99)00241-3.
Link(s): http://www.journals.elsevierhealth.com/periodicals/bps/article/S0006-3223(99)00241-3/abstract
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Seasonal variation of availability of serotonin transporter binding sites in healthy female subjects as measured by (123I)-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography reports a single photon emission computed tomography study on serotonin transporter binding and seasonal variation.

Four brain regions were examined: thalamus, hypothalamus, midbrain and pons. They show a difference such that higher binding appears during summer, — and with the present number of subjects it only appears significant in for the hypothalamus/thalamus region.

Contents

[edit] Subjects

Subject group #1 (help)
"Summer" females
Subjects/♂/♀: 5 / 0 / 5
Age: 27.7 ±6.2 (21–37)
Nationality: define nationality
Approval: Ethics Comittee of the University of Vienna
Databases:

Group 1 of 5 "Summer" females with 0 males and 5 females were included in the study. The group had a mean age of 27.7 with a range from 21 to 37.

The study on the human subjects was approved by the Ethics Comittee of the University of Vienna.
Subject group #2 (help)
"Winter" females
Subjects/♂/♀: 6 / 0 / 6
Age: 27.7 ±3.1 (25–33)
Nationality: define nationality
Approval: Ethics Comittee of the University of Vienna
Databases:

Group 2 of 6 "Winter" females with 0 males and 6 females were included in the study. The group had a mean age of 27.7 with a range from 25 to 33. The study on the human subjects was approved by the Ethics Comittee of the University of Vienna.

The "summer females" were either scanned in May, June or July. While the "winter females" were scanned in November or December.

[edit] Scanning

SPECT scanning with the iodine-123 β-CIT radioligand using the Siemens Multispect 3 camara.

[edit] Results

Statistical values the test for specific/nondisplaceable binding difference between summer and winter scan is reported for two regions. Also values for specific binding are reported.

  1. Thalamus/hypothalamus, specific/nondisplaceable, summer versus winter, z=2.739, P=0.006
  2. Midbrain/pons, specific/nondisplaceable, summer versus winter, z=1.37, P=0.17
  3. Thalamus/hypothalamus, specific, summer versus winter, z=2.38, P=0.017
  4. Midbrain/pons, specific, summer versus winter, z=1.19, P=0.233

[edit] Critique

  1. The regions are not entirely clear. It is not clear if regions are drawn independently in the right and left hemispheres. In the text a region is referred to as "thalamus/hypothalamus region", while the figure title calls a region "hypothalamus". Maybe they are to be regarded as two different results as the p-values the figure and the text are not the same (P<0.01 compared with P=0.017). If that is the case the first figure is selected as the most significant. If they are the same then the y-axis label seems to be wrong.
  2. The study has a rather low number of subjects.
  3. The experiment is not a within-subject study (as discussed on page 160).
  4. The results shows higher binding in summer, however, the text reports a negative z-score for the difference "between summer and winter" (page 159).

[edit] Related papers

  1. No seasonal variation in human midbrain serotonin transporter availability in Taiwan
  2. Seasonal changes in brain serotonin transporter binding in short 5-HTTLPR-allele carriers but not in long-allele homozygotes
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