Serotonin receptor 3A (HTR3A) gene is associated with personality traits, but not panic disorder

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Serotonin receptor 3A (HTR3A) gene is associated with personality traits, but not panic disorder
Authors: Naoki Mizuta, Jotaro Akiyoshi, Asami Sato, Hiroaki Hanada, Yoshihiro Tanaka, Jusen Tsuru, Hirotaka Matsushita, Kensuke Kodama, Koichi Isogawa
Citation: Psychiatric Genetics 18 (1): 44. 2008 February
Database(s): PubMed (PMID/18197086)
DOI: 10.1097/YPG.0b013e3282f02099.
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Serotonin receptor 3A (HTR3A) gene is associated with personality traits, but not panic disorder reports a personality genetics study and an association study on panic disorder on the HTR3A gene and its C178T genetic polymorphism. Personality traits were assessed with Temperament and Character Inventory and NEO-FFI.

It is inspired by the study A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women.

[edit] Subjects

Subject group #1 (help)
Healthy Japanese university staff and students
Subjects/♂/♀: 122 / 75 / 47
Age: 23.2 ±13.4 (–)
Nationality: Japanese
Approval: define approval
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Group 1 of 122 healthy Japanese university staff and students with 75 males and 47 females were included in the study.

The Japanese group had a mean age of 23.2.
Subject group #2 (help)
Japanese Panic order patients
Subjects/♂/♀: 82 / 40 / 42
Age: 26.3 ±11.8 (–)
Nationality: Japanese
Approval: define approval
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Group 2 of 82 japanese Panic order patients with 40 males and 42 females were included in the study. The Japanese group had a mean age of 26.3.


[edit] Results

No personality scores are given. It is stated that "the C/C genotype of C178T was associated with higher harm avoidance of Temperament and Character Inventory and Neuroticism (N) of NEO-FFI score than those with C/T genotype."

The difference in genotype distribution between panic disorder patients and controls were not significant.

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