Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism

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Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism
Authors: Srijan Sen, Sandra Villafuerte, Randolph Nesse, Scott F. Stoltenberg, Jeffrey Hopcian, Lillian Gleiberman, Alan Weder, Margit Burmeister
Citation: Biological psychiatry 55 (3): 244-249. 2004 February
Database(s): PubMed (PMID/14744464)
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Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism reports a personality genetics study on SLC6A4 5-HTTLPR and GABRA6 Pro385Ser polymorphism with personality traits assessed with NEO PI.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
SLC6A4 5-HTTLPR short/short NEO PI Neuroticism 87.8 18.86 83 American young adults 14744464
SLC6A4 5-HTTLPR long/short NEO PI Neuroticism 84.5 20.83 183 American young adults 14744464
SLC6A4 5-HTTLPR long/long NEO PI Neuroticism 79.9 19.41 149 American young adults 14744464
SLC6A4 5-HTTLPR short/short NEO PI Extraversion 105.3 17.57 82 American young adults 14744464
SLC6A4 5-HTTLPR long/short NEO PI Extraversion 109.2 17.32 183 American young adults 14744464
SLC6A4 5-HTTLPR long/long NEO PI Extraversion 108.6 16.80 149 American young adults 14744464
SLC6A4 5-HTTLPR short/short NEO PI Openness to experience 104.1 16.03 82 American young adults 14744464
SLC6A4 5-HTTLPR long/short NEO PI Openness to experience 104.4 17.04 183 American young adults 14744464
SLC6A4 5-HTTLPR long/long NEO PI Openness to experience 104.1 16.85 149 American young adults 14744464
SLC6A4 5-HTTLPR short/short NEO PI Conscientiousness 48.0 8.02 83 American young adults 14744464
SLC6A4 5-HTTLPR long/short NEO PI Conscientiousness 48.6 8.41 184 American young adults 14744464
SLC6A4 5-HTTLPR long/long NEO PI Conscientiousness 48.3 8.23 151 American young adults 14744464
SLC6A4 5-HTTLPR short/short NEO PI Agreeableness 45.4 6.56 83 American young adults 14744464
SLC6A4 5-HTTLPR long/short NEO PI Agreeableness 47.6 6.63 183 American young adults 14744464
SLC6A4 5-HTTLPR long/long NEO PI Agreeableness 47.7 6.88 151 American young adults 14744464
GABRA6 Pro385Ser pro/pro NEO PI Neuroticism 85.15 20.47 340 American young adults 14744464
GABRA6 Pro385Ser pro/ser NEO PI Neuroticism 75.67 16.21 51 American young adults 14744464
GABRA6 Pro385Ser pro/pro NEO PI Extraversion 108.07 17.52 340 American young adults 14744464
GABRA6 Pro385Ser pro/ser NEO PI Extraversion 111.73 16.28 51 American young adults 14744464
GABRA6 Pro385Ser pro/pro NEO PI Openness to experience 103.63 17.12 339 American young adults 14744464
GABRA6 Pro385Ser pro/ser NEO PI Openness to experience 107.39 15.00 51 American young adults 14744464
GABRA6 Pro385Ser pro/pro NEO PI Conscientiousness 48.25 8.33 343 American young adults 14744464
GABRA6 Pro385Ser pro/ser NEO PI Conscientiousness 48.19 7.79 52 American young adults 14744464
GABRA6 Pro385Ser pro/pro NEO PI Agreeableness 47.16 6.47 343 American young adults 14744464
GABRA6 Pro385Ser pro/ser NEO PI Agreeableness 48.18 6.71 52 American young adults 14744464


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