Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms

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Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms
Authors: Alessandro Serretti, Laura Mandelli, Cristina Lorenzi, Samuela Landoni, Raffaella Calati, Chiara Insacco, C. Robert Cloninger
Citation: Neuropsychobiology 53 (1): 9-6. 2006
Database(s): PubMed (PMID/16319504)
DOI: 10.1159/000089916.
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Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorpism reports a personality genetics study on DRD4 exon 3 VNTR, SLC6A4 5-HTTLPR, TPH1 A218C and MAOA uVNTR genetic polymorphisms in mood disorder patients.

The forward primer used for TPH1 was 5'-TTC AGA TCC CTT CTA TAC CCC AG-3' which is found as a sequence for rs1800532 [1]

[edit] Subjects

Subject group #1 (help)
Italian mood disorder patients

number_of_subjets missing

Age: (–)
Nationality: Italian
Approval: define approval
Databases:

Group 1 of italian mood disorder patients were included in the study.


Initially 207 patients were included but only a subset was rated with TCI (page 10). The mood disorder was either major depressive disorder or bipolar disorder.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
DRD4 Exon 3 VNTR short/short TCI Novelty seeking 19.1 5.6 84 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR short/short TCI Harm avoidance 20.5 6.9 84 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR short/short TCI Reward dependence 14.7 3.1 84 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR short/short TCI Persistence 4.0 1.7 84 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR short/short TCI Self-directedness 26.9 8.6 84 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR short/short TCI Cooperativeness 29.2 5.8 84 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR short/short TCI Self-transcendence 14.1 6.8 84 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/short TCI Novelty seeking 19.6 5.3 31 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/short TCI Harm avoidance 19.3 6.7 31 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/short TCI Reward dependence 15.0 2.9 31 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/short TCI Persistence 4.3 1.8 31 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/short TCI Self-directedness 29.3 7.1 31 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/short TCI Cooperativeness 30.2 5.0 31 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/short TCI Self-transcendence 14.8 6.7 31 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/long TCI Novelty seeking 21.2 3.0 4 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/long TCI Harm avoidance 15.5 13.4 4 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/long TCI Reward dependence 15.2 5.0 4 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/long TCI Persistence 3.5 2.5 4 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/long TCI Self-directedness 25.7 9.7 4 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/long TCI Cooperativeness 31.5 6.4 4 Italian mood disorder patients 16319504
DRD4 Exon 3 VNTR long/long TCI Self-transcendence 13.7 5.2 4 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR short/short TCI Novelty seeking 16.8 4.5 29 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR short/short TCI Harm avoidance 20.6 7.5 29 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR short/short TCI Reward dependence 14.5 2.9 29 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR short/short TCI Persistence 4.5 1.7 29 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR short/short TCI Self-directedness 29.1 7.7 29 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR short/short TCI Cooperativeness 30.2 6.0 29 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR short/short TCI Self-transcendence 13.0 7.4 29 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/short TCI Novelty seeking 19.8 5.1 65 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/short TCI Harm avoidance 19.4 6.7 65 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/short TCI Reward dependence 15.0 3.3 65 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/short TCI Persistence 4.1 1.8 65 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/short TCI Self-directedness 27.4 8.2 65 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/short TCI Cooperativeness 29.9 5.9 65 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/short TCI Self-transcendence 15.1 7.1 65 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/long TCI Novelty seeking 20.7 5.5 38 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/long TCI Harm avoidance 20.7 7.1 38 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/long TCI Reward dependence 14.2 3.1 38 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/long TCI Persistence 3.9 1.7 38 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/long TCI Self-directedness 26.6 9.0 38 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/long TCI Cooperativeness 28.3 4.6 38 Italian mood disorder patients 16319504
SLC6A4 5-HTTLPR long/long TCI Self-transcendence 15.1 6.3 38 Italian mood disorder patients 16319504
TPH1 A218C C/C TCI Novelty seeking 19.8 5.4 53 Italian mood disorder patients 16319504
TPH1 A218C C/C TCI Harm avoidance 20.3 6.9 53 Italian mood disorder patients 16319504
TPH1 A218C C/C TCI Reward dependence 14.7 3.0 53 Italian mood disorder patients 16319504
TPH1 A218C C/C TCI Persistence 3.9 2.0 53 Italian mood disorder patients 16319504
TPH1 A218C C/C TCI Self-directedness 29.7 8.2 53 Italian mood disorder patients 16319504
TPH1 A218C C/C TCI Cooperativeness 29.6 4.7 53 Italian mood disorder patients 16319504
TPH1 A218C C/C TCI Self-transcendence 14.4 7.6 53 Italian mood disorder patients 16319504
TPH1 A218C A/C TCI Novelty seeking 19.4 5.5 48 Italian mood disorder patients 16319504
TPH1 A218C A/C TCI Harm avoidance 20.4 6.9 48 Italian mood disorder patients 16319504
TPH1 A218C A/C TCI Reward dependence 14.5 3.4 48 Italian mood disorder patients 16319504
TPH1 A218C A/C TCI Persistence 4.1 1.8 48 Italian mood disorder patients 16319504
TPH1 A218C A/C TCI Self-directedness 27.9 8.3 48 Italian mood disorder patients 16319504
TPH1 A218C A/C TCI Cooperativeness 29.4 6.5 48 Italian mood disorder patients 16319504
TPH1 A218C A/C TCI Self-transcendence 14.1 6.8 48 Italian mood disorder patients 16319504
TPH1 A218C A/A TCI Novelty seeking 18.7 5.0 26 Italian mood disorder patients 16319504
TPH1 A218C A/A TCI Harm avoidance 18.5 7.2 26 Italian mood disorder patients 16319504
TPH1 A218C A/A TCI Reward dependence 15.0 3.1 26 Italian mood disorder patients 16319504
TPH1 A218C A/A TCI Persistence 4.6 1.4 26 Italian mood disorder patients 16319504
TPH1 A218C A/A TCI Self-directedness 27.9 9.2 26 Italian mood disorder patients 16319504
TPH1 A218C A/A TCI Cooperativeness 29.9 5.8 26 Italian mood disorder patients 16319504
TPH1 A218C A/A TCI Self-transcendence 14.7 5.8 26 Italian mood disorder patients 16319504
MAOA uVNTR short TCI Novelty seeking 17.4 3.5 9 Male Italian mood disorder patients 16319504
MAOA uVNTR short TCI Harm avoidance 19.11 9.9 9 Male Italian mood disorder patients 16319504
MAOA uVNTR short TCI Reward dependence 13.9 3.8 9 Male Italian mood disorder patients 16319504
MAOA uVNTR short TCI Persistence 4.0 1.7 9 Male Italian mood disorder patients 16319504
MAOA uVNTR short TCI Self-directedness 33.6 9.4 9 Male Italian mood disorder patients 16319504
MAOA uVNTR short TCI Cooperativeness 31.1 4.5 9 Male Italian mood disorder patients 16319504
MAOA uVNTR short TCI Self-transcendence 13.7 7.4 9 Male Italian mood disorder patients 16319504
MAOA uVNTR long TCI Novelty seeking 19.4 5.9 34 Male Italian mood disorder patients 16319504
MAOA uVNTR long TCI Harm avoidance 17.7 6.4 34 Male Italian mood disorder patients 16319504
MAOA uVNTR long TCI Reward dependence 14.1 2.9 34 Male Italian mood disorder patients 16319504
MAOA uVNTR long TCI Persistence 4.3 2.2 34 Male Italian mood disorder patients 16319504
MAOA uVNTR long TCI Self-directedness 29.2 7.8 34 Male Italian mood disorder patients 16319504
MAOA uVNTR long TCI Cooperativeness 29.1 5.3 34 Male Italian mood disorder patients 16319504
MAOA uVNTR long TCI Self-transcendence 14.4 7.4 34 Male Italian mood disorder patients 16319504
MAOA uVNTR short/short TCI Novelty seeking 20.4 6.5 5 Female Italian mood disorder patients 16319504
MAOA uVNTR short/short TCI Harm avoidance 25.0 7.0 5 Female Italian mood disorder patients 16319504
MAOA uVNTR short/short TCI Reward dependence 16.4 1.8 5 Female Italian mood disorder patients 16319504
MAOA uVNTR short/short TCI Persistence 5.0 1.2 5 Female Italian mood disorder patients 16319504
MAOA uVNTR short/short TCI Self-directedness 17.4 4.7 5 Female Italian mood disorder patients 16319504
MAOA uVNTR short/short TCI Cooperativeness 28.0 6.4 5 Female Italian mood disorder patients 16319504
MAOA uVNTR short/short TCI Self-transcendence 14.4 7.0 5 Female Italian mood disorder patients 16319504
MAOA uVNTR long/short TCI Novelty seeking 18.9 5.2 26 Female Italian mood disorder patients 16319504
MAOA uVNTR long/short TCI Harm avoidance 20.7 6.7 26 Female Italian mood disorder patients 16319504
MAOA uVNTR long/short TCI Reward dependence 15.5 3.4 26 Female Italian mood disorder patients 16319504
MAOA uVNTR long/short TCI Persistence 3.3 1.3 26 Female Italian mood disorder patients 16319504
MAOA uVNTR long/short TCI Self-directedness 26.1 7.5 26 Female Italian mood disorder patients 16319504
MAOA uVNTR long/short TCI Cooperativeness 31.0 4.7 26 Female Italian mood disorder patients 16319504
MAOA uVNTR long/short TCI Self-transcendence 14.3 6.4 26 Female Italian mood disorder patients 16319504
MAOA uVNTR long/long TCI Novelty seeking 21.7 5.2 27 Female Italian mood disorder patients 16319504
MAOA uVNTR long/long TCI Harm avoidance 19.6 6.6 27 Female Italian mood disorder patients 16319504
MAOA uVNTR long/long TCI Reward dependence 15.8 2.6 27 Female Italian mood disorder patients 16319504
MAOA uVNTR long/long TCI Persistence 4.3 1.7 27 Female Italian mood disorder patients 16319504
MAOA uVNTR long/long TCI Self-directedness 27.6 8.6 27 Female Italian mood disorder patients 16319504
MAOA uVNTR long/long TCI Cooperativeness 29.6 6.5 27 Female Italian mood disorder patients 16319504
MAOA uVNTR long/long TCI Self-transcendence 14.4 7.2 27 Female Italian mood disorder patients 16319504

[edit] Critique

  1. It is not precisely stated what 'long' and 'short' is.
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