The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients

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The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients
Authors: G. Koller, B. Bondy, U. W. Preuss, P. Zill, M. Soyka
Citation: Behavioral and Brain Functions 2 : 7. 2006
Database(s): PubMed (PMID/16504134)
DOI: 10.1186/1744-9081-2-7.
Link(s): http://www.behavioralandbrainfunctions.com/content/2/1/7
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The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients reports a personality genetics study with alcoholic patients and the C-1019G genetic polymorphism in the HTR1A gene and personality traits assessed with NEO-FFI and Temperament and Character Inventory.

Contents

[edit] Abstract under CC-by

The 5HT1A receptor is one of at least 14 different receptors for serotonin which has a role in moderating several brain functions and may be involved in the aetiology of several psychiatric disorders. The C(-1019)G 5-HT1A promoter polymorphism was reported to be associated with major depression, depression-related personality traits and suicidal behavior in various samples. The G(-1019) allele carriers are prone to depressive personality traits and suicidal behavior, because serotonergic neurotransmission is reduced.

The aim of this study is to replicate previous findings in a sample of 185 Alcohol-dependent individuals. Personality traits were evaluated using the NEO FFI and TCI. History of suicidal behavior was assessed by a standardized semistructured interview (SSAGA). No significant differences across C(-1019)G 5-HT1A genotype groups were found for TCI temperament and character traits and for NEO FFI personality scales. No association was detected between this genetic variant and history of suicide attempts. These results neither support a role of C(-1019)G 5-HT1A promoter polymorphism in the disposition of personality traits like harm avoidance or neuroticism, nor confirm previous research reporting an involvement of the G allele in suicidal behavior in alcoholics. Significant associations, however, were detected between Babor's Type B with number of suicide attempts in history, high neuroticism and harm avoidance scores in alcoholics.

[edit] Subjects

Subject group #1 (help)
German alcohol-dependent patients
Subjects/♂/♀: 185 / 150 / 35
Age: 41.6 (–)
Nationality: German
Approval: Ethical committee of the Ludwig-Maximilians University of Munich
Databases:

Group 1 of 185 german alcohol-dependent patients with 150 males and 35 females were included in the study. The German group had a mean age of 41.6. The study on the human subjects was approved by the Ethical committee of the Ludwig-Maximilians University of Munich.

The subjects were classified in Babor Typology Type A and Type B[1] using the criteria of Schuckit.[2]

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
HTR1A C-1019G G/G NEO-FFI Neuroticism 22.6 8 30 German Babor type A alcohol-dependent patients 16504134
HTR1A C-1019G C/G NEO-FFI Neuroticism 23.3 8 62 German Babor type A alcohol-dependent patients 16504134
HTR1A C-1019G C/G NEO-FFI Neuroticism 22.1 6 30 German Babor type A alcohol-dependent patients 16504134
HTR1A C-1019G G/G TCI Harm avoidance 16.1 6 30 German Babor type A alcohol-dependent patients 16504134
HTR1A C-1019G C/G TCI Harm avoidance 15.9 6 62 German Babor type A alcohol-dependent patients 16504134
HTR1A C-1019G C/C TCI Harm avoidance 16.2 6 30 German Babor type A alcohol-dependent patients 16504134
HTR1A C-1019G G/G NEO-FFI Neuroticism 28.2 8 15 German Babor type B alcohol-dependent patients 16504134
HTR1A C-1019G C/G NEO-FFI Neuroticism 27.3 8 32 German Babor type B alcohol-dependent patients 16504134
HTR1A C-1019G C/C NEO-FFI Neuroticism 25.1 8 16 German Babor type B alcohol-dependent patients 16504134
HTR1A C-1019G G/G TCI Harm avoidance 19.7 6 15 German Babor type B alcohol-dependent patients 16504134
HTR1A C-1019G C/G TCI Harm avoidance 18.0 6 32 German Babor type B alcohol-dependent patients 16504134
HTR1A C-1019G C/C TCI Harm avoidance 17.4 5 16 German Babor type B alcohol-dependent patients 16504134

[edit] References

  1. T. F. Babor (1992). "Types of alcoholics: evidence for an empirically derived typology based on indicators of vulnerability and severity". Arch. Gen. Psychiatry missing volume: missing pages.
  2. M. A. Schuckit (1995). "An evaluation of type A and type B alcoholics". Addiction 90: 1189-1203.
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