The anatomy of melancholia - focal abnormalities of cerebral blood flow in major depression
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| Paper (help) | |
|---|---|
| The anatomy of melancholia — focal abnormalities of cerebral blood flow in major depression | |
| Authors: | Christopher J. Bench, Karl J. Friston, Richard D. Brown, Lynette C. Scott, Richard S. J. Frackowiak, Raymond J. Dolan |
| Citation: | Psychological Medicine 22 : 607–615. 1992 |
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| DOI: | Define doi. |
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| Format: | BibTeX |
| Extract: | |
The anatomy of melancholia — focal abnormalities of cerebral blood flow in major depression is a scientific article with a positron emission tomography study
- Christopher J. Bench, Karl J. Friston, Richard D. Brown, Lynette C. Scott, Richard S. J. Frackowiak, Raymond J. Dolan (1992). "The anatomy of melancholia — focal abnormalities of cerebral blood flow in major depression". Psychological Medicine 22: 607–615. PMID:1410086.
This article was included in the original BrainMap database as paper 32.
Contents |
[edit] Subjects
| Subject group #1 (help) | |
| Depressed | |
| Subjects/♂/♀: | 33 / 21 / 12 |
| Age: | 56.8 ±12.8 (–) |
| Nationality: | define nationality |
| Approval: | define approval |
| Databases: | |
Group 1 of 33 depressed with 21 males and 12 females were included in the study. The group had a mean age of 56.8.
| Subject group #2 (help) | |
| Controls | |
| Subjects/♂/♀: | 23 / 10 / 13 |
| Age: | 63.4 ±11.6 (–) |
| Nationality: | define nationality |
| Approval: | define approval |
| Databases: | |
Group 2 of 23 controls with 10 males and 13 females were included in the study. The group had a mean age of 63.4.
| Subject group #3 (help) | |
| Cognitively impaired depressed | |
| Subjects/♂/♀: | 10 / / |
| Age: | 60.9 ±7.8 (–) |
| Nationality: | define nationality |
| Approval: | define approval |
| Databases: | |
Group 3 of 10 cognitively impaired depressed were included in the study. The group had a mean age of 60.9.
| Subject group #4 (help) | |
| Cognitively unimpaired depressed | |
| Subjects/♂/♀: | 10 / / |
| Age: | 53.2 ±14.8 (–) |
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| Approval: | define approval |
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Group 4 of 10 cognitively unimpaired depressed were included in the study. The group had a mean age of 53.2.
There were two subject groups: Depressed and age-matched controls. Of the 33 in the depressed group there were 10 with associated severe cognitive impairment as evaluated with the Mini-Mental State Examination below or equal to 25. These were compared with a depressed group of 10 patient without cognitive impairment with a score higher than or equal to 29.
[edit] Result
[edit] Healthy versus depressed
| Anatomy | BA | x | y | z | No. vox | t | z | Coordinate search | Plot | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Left anterior cingulate cortex | 32 | -14 | 24 | 36 | 3.46 | Brede Database Brede Wiki SumsDB | ITA | ||
| 2 | Left anterior cingulate cortex | 32 | -16 | 18 | 40 | 3.48 | Brede Database Brede Wiki SumsDB | ITA | ||
| 3 | Left dorsolateral prefrontal cortex | 9/46 | -38 | 34 | 20 | 3.74 | Brede Database Brede Wiki SumsDB | ITA |
Results for the first contrast between controls versus depressed is shown in Table 2a in the paper.
[edit] Medicated versus unmedicated
3 coordinates presented in a table but they are not significant.
[edit] Unimpaired versus cognitive impaired depressed patients
| Anatomy | BA | x | y | z | No. vox | t | z | Coordinate search | Plot | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Left medial frontal cortex | 10 | -8 | 48 | 0 | 3.98 | Brede Database Brede Wiki SumsDB | ITA | ||
| 2 | Left medial frontal cortex | 10 | -6 | 52 | 4 | 4.55 | Brede Database Brede Wiki SumsDB | ITA | ||
| 3 | Left medial frontal cortex | 10 | -6 | 54 | 8 | 4.29 | Brede Database Brede Wiki SumsDB | ITA | ||
| 4 | Left medial frontal cortex | 10 | -6 | 54 | 12 | 3.56 | Brede Database Brede Wiki SumsDB | ITA | ||
| 5 | Cerebellar vermis | 8 | -66 | -12 | 3.75 | Brede Database Brede Wiki SumsDB | ITA | |||
| 6 | Cerebellar vermis | 10 | -60 | -8 | 3.82 | Brede Database Brede Wiki SumsDB | ITA | |||
| 7 | Cerebellar vermis | 8 | -48 | -4 | 3.73 | Brede Database Brede Wiki SumsDB | ITA |
