The effects of gender and COMT val158met polymorphism on fearful facial affect recognition: a fMRI study

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The effects of gender and COMT val158met polymorphism on fearful facial affect recognition: a fMRI study
Authors: Matthew J. Kempton, Morgan Haldane, Jigar Jogia, Tessa Christodoulou, John Powell, David Collier, Steven C. R. Williams, Sophia Frangou
Citation: The International Journal of Neuropsychopharmacology 12 (3): 371-371. 2009 April
Database(s): PubMed (PMID/18796186)
DOI: 10.1017/S1461145708009395.
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Extract:

The effects of gender and COMT val158met polymorphism on fearful facial affect recognition: a fMRI study is an neuroimaging genetics with functional magnetic resonance imaging.


Contents

[edit] Subjects

Subject group #1 (help)
Healthy adults
Subjects/♂/♀: 74 / 40 / 34
Age: (18–65)
Nationality: British
Approval: Ethics Committee of the Institute of Psychiatry and the South London and Maudsley NHS Trust
Databases:

Group 1 of 74 healthy adults with 40 males and 34 females were included in the study. The British group was from 18 up to 65 years old. The study on the human subjects was approved by the Ethics Committee of the Institute of Psychiatry and the South London and Maudsley NHS Trust.

[edit] Results

The neuroimages was processed and analyzed with SPM5. MNI coordinates were converted to Talairach coordinates.

[edit] Fearful faces compared to neutral faces

4+2 coordinates in text on page 375, column 1. p<0.05 corrected was used as a threshold.

Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 Left occipital gyrus 18 -32 -88 -2 1172 7.15 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 Right lingual gyrus 18 14 -82 -4 262 6.50 Brede Database Brede Wiki NeuroSynth SumsDB Not available
3 Right fusiform gyrus 37 40 -57 -14 455 6.30 Brede Database Brede Wiki NeuroSynth SumsDB Not available
4 Left post-central gyrus 40 -51 -32 51 1183 6.12 Brede Database Brede Wiki NeuroSynth SumsDB Not available

There are two further coordinates in the amygdala if small-volume-correction analysis is used.

[edit] Gender effect

[edit] Genotype

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