Variation at the DRD4 promoter modulates extraversion in Caucasians

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Variation at the DRD4 promoter modulates extraversion in Caucasians
Authors: Peter Eichhammer, P. G. Sand, P. Stoertebecker, B. Langguth, M. Zowe, G. Hajak
Citation: Molecular Psychiatry 10 (6): 520-522. 2005 June
Database(s): PubMed (PMID/15738935)
DOI: 10.1038/sj.mp.4001658.
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Extract:

Variation at the DRD4 promoter modulates extraversion in Caucasians reports a personality genetics study on DRD4 genetic polymorphisms: C-521T (rs1800955) and the 120-bp duplication (rs4646984).

[edit] Subjects

Subject group #1 (help)
Germans
Subjects/♂/♀: 104 / 52 / 52
Age: 29 ±8 (–)
Nationality: Germans
Approval: define approval
Databases:

Group 1 of 104 germans with 52 males and 52 females were included in the study. The Germans group had a mean age of 29.


[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
DRD4 120-bp duplication short NEO-FFI Neuroticism 1.49 0.47 38 German volunteers 15738935
DRD4 120-bp duplication long/long NEO-FFI Neuroticism 1.58 0.55 66 German volunteers 15738935
DRD4 120-bp duplication short NEO-FFI Extraversion 2.65 0.46 38 German volunteers 15738935
DRD4 120-bp duplication long/long NEO-FFI Extraversion 2.38 0.54 66 German volunteers 15738935
DRD4 120-bp duplication short NEO-FFI Openness to experience 2.46 0.45 38 German volunteers 15738935
DRD4 120-bp duplication long/long NEO-FFI Openness to experience 2.59 0.49 66 German volunteers 15738935
DRD4 120-bp duplication short NEO-FFI Agreeableness 2.60 0.52 38 German volunteers 15738935
DRD4 120-bp duplication long/long NEO-FFI Agreeableness 2.63 0.58 66 German volunteers 15738935
DRD4 120-bp duplication short NEO-FFI Conscientiousness 2.67 0.51 38 German volunteers 15738935
DRD4 120-bp duplication long/long NEO-FFI Conscientiousness 2.67 0.61 66 German volunteers 15738935
DRD4 C-521T T NEO-FFI Neuroticism 1.48 0.55 75 German volunteers 15738935
DRD4 C-521T C/C NEO-FFI Neuroticism 1.69 0.42 27 German volunteers 15738935
DRD4 C-521T T NEO-FFI Extraversion 2.48 0.55 75 German volunteers 15738935
DRD4 C-521T C/C NEO-FFI Extraversion 2.50 0.50 27 German volunteers 15738935
DRD4 C-521T T NEO-FFI Openness to experience 2.55 0.46 75 German volunteers 15738935
DRD4 C-521T C/C NEO-FFI Openness to experience 2.50 0.55 27 German volunteers 15738935
DRD4 C-521T T NEO-FFI Agreeableness 2.66 0.51 75 German volunteers 15738935
DRD4 C-521T C/C NEO-FFI Agreeableness 2.61 0.54 27 German volunteers 15738935
DRD4 C-521T T NEO-FFI Conscientiousness 2.66 0.59 75 German volunteers 15738935
DRD4 C-521T C/C NEO-FFI Conscientiousness 2.71 0.53 27 German volunteers 15738935


[edit] Critique

  1. It is not written whether the deviation is the standard deviation for the data or the standard error for the mean. By comparison with the F-value listed the deviation must be the standard error of the mean
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